A part of antihypertensive drugs can have an effect on men’s sexual function. Drugs that affect libido include methyldopa, colistin, propranolol, hydrazin, and reserpine; drugs that affect erectile function include methyldopa, colistin, propranolol, hydrazin, and thiazide diuretics; and drugs that affect ejaculation include methyldopa, phenelzine, and guanethidine. In fact, patients with hypertension often suffer from a number of other chronic diseases at the same time, such as insomnia. Hypnotic sedatives, anxiolytics, amphetamines, Librium, etc., can also affect sexual function. At the same time, some underlying diseases such as hyperlipidemia, hyperglycemia, likewise have an adverse effect on the erectile function of men. In addition, the age factor is also a cause that cannot be ignored. As age increases, all aspects of sexual function may decline. Therefore, sexual function is affected by a comprehensive process in general, and cannot be attributed entirely to the effect of antihypertensive drugs.