Whether or not one must always take estrogen for premature ovarian failure needs to be determined under the diagnosis of a medical professional based on the patient’s condition, age and other factors. Premature ovarian failure refers to the loss of normal physiological functions of the ovaries before the age of 40, and the occurrence of menstrual disorders, amenorrhea, infertility, insomnia, night sweats, depression and anxiety, and other symptoms similar to menopause. Normally it is necessary to always supplement estrogen for treatment. If the patient has symptoms of premature ovarian failure such as abnormal menstrual cycles, night sweats, vaginal dryness, etc., depending on the condition, estrogen (such as estradiol valerate) and progesterone (progesterone capsule) should be taken to improve the menstrual symptoms until there is relief. The usual treatment cycle is 3-6 months. If the patient has premature ovarian failure at the menopausal age and there are no contraindications to taking estrogen, the patient can continue to take estrogen as prescribed by the doctor. It is important to note that estrogen should not be taken in excess to avoid fibroids, endocrine disruption and other phenomena. Patients diagnosed with premature ovarian failure should be treated as soon as possible and reviewed regularly.