The prognosis of melanoma is related to the tumor stage and treatment effect, etc. If the disease is in early stage, the patient can be cured by active treatment, and the life expectancy of the patient will not be affected. However, if the disease is in the middle or late stage, the treatment is more difficult and the curative effect is poor, which may affect the patient’s life expectancy. Melanoma is a malignant transformation of melanocytes into a tumor with a high degree of malignancy. Overall, some early melanomas can be cured through surgical resection, and the prognosis is relatively good, which will not affect the patient’s life expectancy under normal circumstances. However, if the melanoma is in the middle or late stage, the effect of surgical treatment alone is not satisfactory, and it needs to be combined with regional lymph node dissection and postoperative radiotherapy and other adjuvant treatments. If the disease does not recur or metastasize in the late stage, it is possible that the patient’s life expectancy will not be affected; however, if the melanoma recurs or metastasizes, it will lead to a reduction in the patient’s life expectancy. For melanoma patients, they should seek medical treatment in time and cooperate with doctors for standardized treatment to avoid delaying the disease and affecting life expectancy.