High thyroid peroxidase antibodies and low thyrotropin may be the result of diseases such as hyperthyroidism and Hashimoto’s thyroiditis, which need to be treated for the cause. If it is hyperthyroidism, it can be treated with medication, surgery, and iodine 131. 1. Medication: If the hyperthyroidism is caused by elevated anti-thyroid peroxidase antibodies and low thyroid stimulating hormone, it needs to be treated with medication such as propylthiouracil under the guidance of a doctor. In addition, patients with palpitations need to be treated with beta-blockers, such as propranolol and metoprolol, under the guidance of a doctor. 2. Surgery: If the patient has moderate to severe hyperthyroidism or suspected malignant changes in the thyroid gland, thyroidectomy is needed. 3. Other treatments: In addition, high anti-thyroid peroxidase antibody and low thyrotropin caused by hyperthyroidism can be treated with radioactive iodine irradiation. It is recommended that patients with high antithyroid peroxidase antibodies and low thyrotropin hormone need to consult a doctor in time, and can choose appropriate measures for treatment under the guidance of the doctor.