Men with moist itching can use topical tretinoin cream, erythromycin ointment, compound ketoconazole ointment or oral amoxicillin and so on. But according to the different causes to decide to use what drugs, cause men wet itching cause scrotum local eczema, and local skin infection and chronic prostatitis. 1. Localized eczema of the scrotum: Due to the moist scrotum of some patients, the local heat dissipation is not good, easy to appear eczema, resulting in itching, generally can be used externally with glucocorticosteroids, such as tretinoin cream or dianabed cream, as well as mometasone furoate cream, etc., and usually pay attention to avoid scratching and secondary infections. 2. Local skin infections: when the scrotum local skin bacterial or fungal infections, there will be obvious itching symptoms, this time should be as soon as possible to the hospital to do specimen culture to determine the type of infection, if it is a bacterial infection, you can use erythromycin ointment, if it is a fungal infection, the available ketoconazole ointment. 3. Chronic prostatitis: Some patients with chronic prostatitis have frequent urination, urinary urgency, incomplete urination and other symptoms, which can cause the phenomenon of localized moisture in the scrotum, at this time, if you do not pay attention to hygiene, it will cause localized itching is very obvious, you can take oral antibiotic treatment, such as amoxicillin, etc., and should pay attention to the scrotum to keep it dry, to wear loose clothes. If the above symptoms, go to the hospital as soon as possible to find a professional doctor, identify the cause of the disease, and then determine the best treatment, the drug should be applied under the guidance of the doctor.