There is a soybean blister close to the vaginal opening that is considered to be related to genital herpes and vulvar eczema. 1. genital herpes: this disease is due to the herpes simplex virus infection caused by sexually transmitted diseases, the patient is mostly manifested in the vulva blisters, vesicles, itching and other clinical manifestations, once diagnosed need to comply with the doctor’s instructions orally acyclovir, vaxilovir and other antiviral drugs treatment. 2. Vulvar eczema: due to the underwear is not breathable, do not pay attention to local cleaning, will lead to the occurrence of vulvar eczema, the patient has local skin redness, swelling, pimples, blisters, vesicles and other polymorphic lesions, accompanied by obvious itching of the skin. Generally need to follow the doctor’s instructions to use glycerine lotion external coating, boric acid solution wet compresses, if necessary, need to use budesonide ointment and other glucocorticoid preparations. For women who have blisters of soybean grains close to the vaginal opening, it is recommended that they go to the gynecology and dermatology departments of regular hospitals to clarify the cause of the disease and then actively treat it under the guidance of the doctor.