The best treatment for papillitis of the tongue includes psychotherapy, removal of local irritants, local medication, and correction of systemic influences, as follows. 1. Psychological treatment: eliminate the patient’s anxiety and reduce the behavior of frequent tongue extension and observation. 2. Remove local stimulating factors: adjust and grind the sharp tooth tip, remove dental calculus, remove bad restorations, prohibit acid, spicy, hot and other stimulating foods, and keep the oral cavity clean. 3. Local medication: antibacterial gargle solution, such as 0.1% ciprofloxacin, chlorhexidine solution and so on. 4. Correct systemic influences: If the papillitis of tongue is caused by malnutrition, anemia, blood diseases, fungal infection, endocrine disorders, vitamin deficiency, the corresponding diseases should be treated, and the symptoms will be relieved. All the above medications should be used under medical supervision.