High cardiac enzymes in newborns can be managed in several ways. Firstly, myocardial protection treatment is carried out. For the treatment of protecting the myocardium, a large amount of vitamin C can be applied, or sodium fructose diphosphate can be applied, both of which have a certain protective effect on the myocardium. Secondly, treatment for the cause of the disease. If the high myocardial enzyme is caused by viral myocarditis, timely antiviral treatment should be carried out. After the viral replication is inhibited, the myocardial enzyme profile will not be persistently elevated. Finally, nursing treatment is necessary. If cardiac enzymes are high, minimize activity. If the activity level is high, it will increase the burden on the heart, which will be detrimental to the recovery of cardiac enzymes.