Symptoms of chronic granulocytic leukemia in the late stage include severe anemia, infections and fever, bleeding, and so on. 1. Severe anemia: the increase of white blood cells in patients with advanced chronic granulocytic leukemia and their spread throughout the body will inhibit normal blood production in bones and lead to anemia. Anemia will produce dizziness, weakness, pallor and other symptoms, which can be relieved by blood transfusion treatment. 2. Infection and fever: fever is one of the main manifestations of chronic leukemia patients, which will produce persistent fever and even induce sepsis. Physical cooling can be used, using alcohol to wipe the body, body temperature more than 38.5 ℃, can take ibuprofen suspension, nimesulide capsules and so on. Anti-infective drugs include levofloxacin, etc. The drugs should be taken under the guidance of a doctor. 3. Bleeding: patients may have symptoms of nasal bleeding, gum bleeding or subcutaneous bleeding in the late stage, or skin and mucous membrane petechiae and ecchymosis, which is caused by thrombocytopenia. Platelet transfusions may be given to relieve symptoms. Patients with chronic granulocytic leukemia can be treated with oral tyrosine kinase inhibitors, such as imatinib, as prescribed by the doctor. Some patients may have drug intolerance, and then hematopoietic stem cell transplantation is needed for treatment. Therefore, when patients with advanced chronic granulocytic leukemia develop anemia, fever and bleeding, they need to go to the hospital as soon as possible to avoid delaying their condition.