Tooth pain should first identify the cause, according to the cause of symptomatic or causative treatment, symptomatic use of pain medication, the cause of anti-inflammatory drugs or surgical treatment. 1. There are many non-disease causes of toothache such as menstruation and menopause, sex hormone changes can lead to toothache, pressure changes of high altitude flights may cause toothache, while trauma can also squeeze the pain. 2. Common disease causes such as tooth-induced diseases of the dentition, pulp or periapical diseases such as dental caries, pulpitis, periapical inflammation as well as periodontal diseases, periodontal abscesses, pericoronitis and other diseases. Acute purulent maxillary sinusitis as well as pain not caused by pulpal diseases such as trigeminal neuralgia, tumors can cause toothache. 3. So the toothache needs to be treated according to the cause or for the symptoms, for the symptoms can use ibuprofen and other painkillers, and then according to the cause of the disease such as periodontitis can be systematic periodontal treatment, pulpitis, periapical periodontitis can be treated through endodontic treatment, apical surgery and so on. It is recommended to consult a doctor for timely examination and treatment of toothache, and the use of medication should be in accordance with the doctor’s instructions.