Patients with open-eyed coma will have some characteristic manifestations when they wake up and get better, such as increased unconscious movements and avoidance response to painful stimuli. 1. Increase in unconscious movements: patients may have some unconscious autonomous activities, such as following the voice with their eyes or some meaningless body movements. 2. Pain avoidance: When there is sound, light, or pain stimulation, the patient’s reaction is significantly enhanced. Some patients may show obvious avoidance reaction. 3. Vital signs tend to be stable: most of the vital signs of patients with open-eye coma tend to be stable when they wake up and get better, and the patient’s mentality, consciousness, pupil and other indicators are relatively stable and normal. Eyes open coma patients long-term bedridden, prone to a variety of complications, common infections, lower extremity deep vein thrombosis, these complications are prone to aggravate the condition, affecting the treatment. Coma patients, family members need to actively cooperate with the doctor’s treatment, so as not to delay the therapeutic effect .