Advanced melanoma should not give up treatment, advanced melanoma is difficult to cure, at present the main target therapy or immunotherapy, can be combined with chemotherapy, so that the patient to achieve the state of survival with tumor, prolonging the survival of patients, but the effect of radiotherapy is poor. Melanoma is a kind of tumor that comes from the malignant transformation of melanocytes, generally speaking, the degree of malignancy is relatively high, late-stage melanoma is difficult to treat and the prognosis is relatively poor, but it should not give up the treatment. Melanoma occurs on the soles of the feet, the ends of the fingers, and the skin under the nails of the limbs, and the location is superficial, easy to find, the earlier the treatment is carried out, the higher the possibility of a cure is. Late-stage melanoma often loses the opportunity of surgical treatment, but it can also be treated by targeted drug therapy, immunotherapy and other methods to prolong the survival period of patients, and the five-year survival rate of late-stage melanoma patients is about 23%. If diagnosed with advanced melanoma, please keep a positive mindset and cooperate with your doctor for treatment.