The main component of alcohol is ethanol, which is converted into acetaldehyde in the body. Anti-inflammatory drugs will inhibit the action of acetaldehyde dehydrogenase, so that alcohol cannot be converted into water and carbon dioxide and discharged from the body. Most anti-infective drugs taken with alcohol are prone to disulfiram reaction, especially penicillin and cephalosporins. Disulfiram reaction refers to the occurrence of facial flushing, chest tightness, panic, shortness of breath, laryngeal edema, increased heart rate, dyspnea, dizziness, nausea and other symptoms when patients drink a lot of alcohol, or when alcohol is taken with anti-inflammatory drugs, and in serious cases, acute myocardial infarction, heart failure, decreased blood pressure, shock, or even life-threatening, and the reaction will be more obvious in elderly people or people with combined cardiovascular and cerebrovascular diseases. Although it does not occur with all drugs, people have different constitutions and it is not recommended to risk drinking alcohol, especially during the week before and after taking oral antibiotics, because alcohol is not metabolized at the same rate in the body.