Patients with hepatocellular carcinoma portal vein thrombus can do interventional therapy. Portal vein cancer thrombus is the most common combined manifestation of primary liver cancer. When patients develop portal vein cancer thrombus, it often means that the prognosis of primary liver cancer is poor, at this time, primary liver cancer is likely to have entered into locally advanced or advanced stage, and most of the patients are physically unable to undergo surgery or the surgical treatment can not achieve the expected effect, at this time, patients can take interventional therapy. Interventional therapy for patients with portal vein cancer thrombosis can effectively control the tumor and combine with other treatments (such as targeted therapy, immunotherapy, etc.) to fight for more treatment opportunities for patients and prolong their survival time. When the patient suffers from portal vein cancer thrombosis, it is important to have timely treatment under the guidance of the doctor.