Blisters in medicine refers to blisters. If the blisters on the legs are not caused by burns, they may be caused by diseases such as herpes zoster, impetigo and eczema. 1. Herpes zoster: caused by varicella zoster virus infection involving the nerves and skin, the main symptom is pain, and there will be a rash, such as herpes papules, blisters, etc., usually along the ganglion segments of the band distribution, can be seen in the chest, limbs and other places. 2. Impetigo: Impetigo is a skin disease caused by bacterial infection, mainly Staphylococcus aureus. Impetigo can occur in the face, limbs, trunk and other parts of the skin lesions manifested as herpes mound, blisters or pustules. 3. Eczema: the formation of eczema has more reasons, may be genetic, immune abnormalities and chronic infectious diseases and other factors. The patient’s skin will appear erythema, papules, blisters and other symptoms, if secondary infection, pustules will be formed. It occurs on the head and face, hands and feet, and limbs. The causes of blisters on the legs like burns are more, in addition to the above common causes, there are some rare diseases, such as autoimmune blisters, etc., need to be combined with the relevant examination for diagnosis, so it is recommended that patients go to the regular hospital in time to clarify the cause of the disease, and active treatment.