There are many reasons for women’s leg weakness with pain. The common causes are too long distance and prolonged walking during the day, or strain on the leg muscles after physical exercise, and in cold winters when the calf muscles get cold due to inadvertence, causing muscle spasm and then leg weakness with pain. In middle-aged women, it cannot be excluded that the sciatic nerve pain is caused by a herniated disc that compresses the sciatic nerve and then radiates to the distal end. In other cases, it is often due to osteoarthritis of the knee or hip joint, osteoporosis, and joint degeneration in middle-aged and elderly women that cause leg tenderness and pain. In addition, the presence of calcium deficiency symptoms or electrolyte disorders in the elderly may also lead to muscle spasms in the legs, which can cause weakness and soreness.