When eating buns without soup, the discomfort of esophagus may be caused by personal dietary habits, or considered to be caused by esophagitis, esophageal cancer and other diseases, which need to be taken for the cause of the disease, such as general measures, medication, surgical treatment, chemoradiation therapy and so on. 1. Individual dietary habits: If the long-term dietary habit is to eat buns with soup, when eating buns without soup alone, there may be discomfort, which is manifested as esophageal discomfort. If it is not accompanied by other uncomfortable symptoms, there is no need to take special treatment. It can be consumed daily with soups. 2. Esophagitis: the discomfort in the esophagus when eating buns without soup may be caused by esophagitis. Patients can take oral proton pump inhibitors, such as omeprazole, pantoprazole, rabeprazole and so on, under the guidance of the doctor. Or take esophageal dilatation as prescribed by doctor. 3. Esophageal cancer: the discomfort of esophagus when eating bun without soup can also be considered to be caused by esophageal cancer, and patients can take open-heart surgery, laparoscopic surgery and so on according to doctor’s instruction, and cooperate with radiotherapy treatment after surgery. There are many reasons leading to the discomfort of esophagus when eating buns without soup, and it is suggested that patients should find out the causes of the disease in time and standardize the treatment according to the doctor’s prescription.