Burning sensation in the stomach may be caused by reflux esophagitis, gastric ulcer, gastritis and so on. 1. Reflux esophagitis: it is a disease in which the contents of the stomach and duodenum reflux into the esophagus due to the influence of various factors such as medication, food, impaired esophageal dynamics, living habits, and congenital, etc. It is mainly manifested as heartburn, acid reflux, and retrosternal pain. 2. Gastric ulcer: due to Helicobacter pylori infection, irregular diet and other reasons can cause ulcerative lesions of the gastric mucosa, gastric acid secretion can be corroded through the ulcerated surface of the stomach stomach wall, causing heartburn. 3. Gastritis: Alcohol, infection, trauma, drugs, diet and other factors can cause stimulation of the gastric mucosa, resulting in acute or chronic inflammatory reaction of the gastric mucosa, manifested as heartburn, stomach pain and other symptoms. There may be other reasons for the burning sensation in the stomach, it is recommended to go to the hospital in a timely manner, under the guidance of a professional physician to clarify the cause of the disease.