Leg and knee pain can be caused by trauma, lumbar spine disease, osteoarthritis, hip joint disease, etc. General treatment, physical therapy, medication and surgery are feasible. 1. Trauma: falling down and injuring the lower limbs or receiving direct blows from external forces can lead to soft tissue injuries or fractures, causing symptoms of leg and knee pain. After the injury, you need to seek medical treatment for X-ray and CT examination to clarify the condition, braking of the affected area, oral analgesic treatment with celecoxib as prescribed by the doctor, and surgical treatment when the injury is serious. 2. Lumbar spine disease: lumbar disc herniation, lumbar spinal stenosis and other diseases can make the nerve compression, the symptoms of leg and knee pain. Need more bed rest, reduce lumbar activities, can follow the doctor’s instructions to apply analgesic drugs such as Loxoprofen sodium or methylcobalamin and other nutritive nerve medication, but also feasible traction, massage and other physical therapy, when the condition is serious, surgery can be carried out. 3. Osteoarthritis: Osteoarthritis of the knee can cause leg pain, knee pain performance, need to pay attention to the protection of the knee joint, reduce activities and weight bearing, oral ibuprofen oral analgesic treatment as prescribed by the doctor, can be injected into the joint cavity of sodium vitrate lubrication and nutrition of articular cartilage treatment, when the disease is severe, surgical procedures, such as knee arthroplasty. 4. Hip diseases: Hip tuberculosis, necrosis of the femoral head and other diseases can cause reflex leg pain and knee pain symptoms, need to treat hip diseases, including regular application of isoniazid, p-aminosalicylic acid, streptomycin and other anti-tuberculosis treatment, surgical removal of tuberculosis foci or the replacement of the artificial head of the femoral head and other treatments. Timely medical treatment is needed for leg and knee pain, which can help to alleviate the pain and discomfort at an early stage.