The clinical significance of a positive Bartholin’s sign is that it means that the pyramidal tract is damaged. The pyramidal tract contains the cortical brainstem tract and the corticospinal tract. In layman’s terms, the corticobulbar tract is the bundle of fibers that emanates from the cerebral hemisphere and terminates in the nucleus accumbens of the brainstem. The corticospinal tracts are the conduction tracts that emanate from the cerebral hemispheres and terminate in the spinal cord. Therefore, lesions of the cerebral hemispheres, brainstem, and spinal cord can all result in a positive Bartholin’s sign. Some of the more common clinical conditions are cerebral infarction, cerebral hemorrhage, intracranial occupancy, and myelitis, among other lesions.