Maintenance chemotherapy for advanced gastric cancer refers to carrying out appropriate chemotherapy to control the progression of the disease as far as possible without increasing the adverse effects, improving the quality of life and prolonging the survival period. Advanced gastric cancer cannot be cured clinically, but chemotherapy can kill tumor cells to a certain extent, reduce tumor load and improve patients’ quality of life. This kind of maintenance chemotherapy should not be used with high dose, which may increase the adverse reaction of chemotherapy and affect the quality of life, so the dose should be adjusted. Chemotherapy cannot completely kill all tumor cells, so it is not curable, and should be evaluated on time, and once chemotherapy cannot control the disease, it can be considered to change to other treatment modalities. Therefore, even if advanced gastric cancer cannot be cured, it is able to improve the quality of life and prolong the survival period as much as possible through maintenance chemotherapy.