Treatment of gallbladder cancer includes surgery, radiotherapy and chemotherapy. 1. Surgery: radical resection is the only possible cure for gallbladder cancer. However, the scope of surgical resection, whether it is combined with organ resection or combined with vascular resection and reconstruction, the scope of lymph node dissection, the treatment of extrahepatic bile ducts, and the treatment of choledochal ducts need to be decided according to the condition. Early stage cholangiocarcinoma can be cured by cholecystectomy, but in middle and late stage, the chance of surgery is often lost or the scope of resection needs to be enlarged and combined with resection of surrounding organs/tissues; and patients with advanced stage usually can only receive palliative surgical treatment. 2. Chemotherapy: therapeutic chemotherapy can prolong the survival of unresectable gallbladder cancer. Currently, gemcitabine combined with cisplatin regimen is the standard first-line chemotherapy regimen for unresectable gallbladder cancer; gemcitabine combined with Tegretol regimen has an overall effective rate of 30% for advanced gallbladder cancer, and the tumor control rate is 70%. 3. Radiotherapy: it is mainly used for high-risk recurrence groups such as radical resection, positive margins or positive lymph nodes of gallbladder cancer with T2 stage or above, patients after palliative surgical treatment of gallbladder cancer and tumor recurrence, and patients who are inoperable. 4. In patients with unresectable or recurrent gallbladder cancer, if there is a high degree of microsatellite instability or a lack of cell mismatch repair mechanism, they can be treated with the immune checkpoint inhibitor karelizumab or navumab. It is recommended to go to regular hospitals for consultation and treatment, and cooperate with the treatment as prescribed by the doctor to avoid delaying the condition. Please strictly follow the doctor’s instructions, do not self-medication.