Whether gastric ulcer is serious when the size is 0.4*0.6cm should be decided according to whether the patient has related complications or recurrent episodes, usually it is not serious. Gastric ulcers are inflammatory defects in the gastric mucosa, and the ulcers can reach the muscular layer of the mucosa or deeper, which may be related to factors such as Helicobacter pylori infection, excessive alcohol consumption, excessive gastric acid pepsin, weakening of gastric mucosal defenses, and long-term use of non-steroidal anti-inflammatory drugs. If gastric ulcer is found in the first examination and the symptoms are not serious, only upper abdominal discomfort without obvious pain, most of them are not serious, but it is still necessary to improve the relevant examination to clarify the cause of the disease, such as whether there is Helicobacter pylori infection. If the symptoms of gastric ulcer are more serious, with obvious pain in the upper abdomen or related complications, such as bleeding, perforation, obstruction, etc., or if the gastric ulcer is recurrent and the disease lasts for a long time, then the condition is more serious and cancer may occur. If the patient is diagnosed with gastric ulcer, it is recommended to go to a regular hospital in time, to clarify the cause of the disease, and then carry out targeted treatment under the guidance of the doctor to minimize the adverse effects of the disease.