Usually the factors that cause late night stomach pain are gastrointestinal spasm, excessive gastric acid secretion, mesenteric vascular embolism, etc., which can be improved by oral antispasmodic drugs, oral acid-suppressing drugs, surgical treatment and other ways. 1. Gastrointestinal spasm: Staying up late may cause autonomic dysfunction, which leads to gastrointestinal smooth muscle spasm, appearing to stay up late stomach pain. Symptoms can be relieved by oral antispasmodic drugs, such as cetrimonium bromide, dicyclomine hydrochloride, scopolamine and so on. 2. Excessive secretion of gastric acid: staying up late may cause excessive secretion of gastric acid, and under the stimulation of gastric acid, there may be a situation of staying up late with stomach pain. Symptoms can be relieved by taking oral acid-suppressing drugs, such as omeprazole and rabeprazole. 3. Mesenteric vascular embolism: Staying up late may cause damage to the heart, the original heart problems can be induced by the embolus shedding, the embolus with the blood circulation to reach the mesentery, resulting in mesenteric vascular embolism, and then appeared to stay up late with stomach pain. The symptoms can be relieved by surgical treatments, such as interventional thrombectomy and vascular bypass surgery. When stomach pain occurs late at night, you need to consult a doctor in time, use medication under the guidance of the doctor, and improve the physical examination, gastric fluid analysis, mesenteric angiography and other tests, to clarify the cause of the disease, and active treatment.