First of all, it can be established that memantine is effective in the treatment of non-gonococcal urethritis, but it requires a full course of application. That is, memantine 100 mg orally twice a day for a total course of 2-3 weeks. However, single drug application treatment often does not achieve good clinical results and requires combination application. Tetracycline 500 mg orally 4 times a day is added with the administration of memantine, and the general course of treatment is 3 weeks. Home doxycycline 100 mg orally twice a day for 7 days. If, after a full course of combined medication, there is no significant relief of symptoms, or if such medication is not acceptable. An alternative regimen is available, namely erythromycin 500 mg orally 4 times daily for at least 7 days. Levofloxacin 0.2 g twice a day for 2-3 weeks. Azithromycin at an initial dose of 1 gram and 0.5 gram the next day for 2 days.