The cause of keratosis pilaris, also known as perifollicular keratosis, is not fully understood and may be related to autosomal dominant inheritance, vitamin A deficiency, and metabolic disorders. Treatment includes systemic medication, topical medication, and if necessary, physical therapy or surgery. 1. Systemic medication: There is no satisfactory clinical treatment for keratosis pilaris. Systemic medication includes vitamin A, retinoic acid, vitamin E, prednisone and so on. If accompanied by bacterial infection, erythromycin, amoxicillin and other antibiotic drugs can be given. 2. Local medication: local medication includes keratolytic agents, such as salicylic acid cream. Glucocorticoid drugs such as hydrocortisone butyrate cream, mometasone furoate cream. Topical urea creams can also be used, which help in removing the lesions. Apart from this, physical therapy such as laser, freezing, superficial X-rays, and borderline irradiation can also be used to improve the symptoms. In case of hypertrophic lesions, it can be treated by skin rubbing. If symptoms such as self-conscious itching and pain occur or abnormal lesions are found, it is recommended to go to the dermatology department of the hospital in time and be given appropriate medication under the guidance of the doctor.