Duodenal adenocarcinoma accounts for 40% of small intestine adenocarcinoma, and it occurs in the age of 60-70 years; according to the location of the cancer, it can be divided into upper papillary cancer, peripapillary cancer and lower papillary cancer. Among them, papillary adenocarcinoma of duodenum is a kind of small intestine malignant tumor which is relatively insidious, the incidence of which has been increasing in recent years and is difficult to be detected clinically. However, with the change of the disease, symptoms may appear depending on the location and growth mode. The main manifestations of duodenal papillary cancer are painless jaundice (caused by the tumor obstructing the jugular abdomen, often due to the tumor shedding after necrosis, so the jaundice may fluctuate, but overall the foot deepens), nausea and vomiting (the mass causes blockage or narrowing of the duodenum, which can be initially determined according to whether the vomit contains bile). The relationship between the tumor and the duodenal papilla can be initially determined based on whether the vomit contains bile), black stool, etc. In advanced stage, abdominal pain may occur (not relieved by food or acid suppressants, and if the tumor invades the peritoneum or pancreas, radiating pain in the lower back may occur).