Multiple stones need to be examined in the hospital, and a relevant treatment plan should be formulated for the removal of the stones.1. In case of multiple kidney stones, ureteroscopy or percutaneous nephrolithotomy is recommended for lithotripsy and stone removal. For multiple stones, two or three surgeries may be needed to completely eradicate the stones, because there is a blind spot in the field of vision in one surgery, and it is not possible to completely eradicate the stones at one time. 2. If there are multiple ureteral stones, ureteroscopic lithotripsy and lithotripsy can be considered, and the goal of eradication can be achieved through a single surgery. 3. If there are multiple bladder stones, suprapubic cystotomy and stone removal or suprapubic cystectomy are recommended. In case of multiple bladder stones, we can carry out pubic cystotomy and stone extraction or transurethral and bladder holmium laser lithotripsy, and generally the stones can be completely eradicated by one operation; 4. Multiple urethral stones can be crushed by holmium laser lithotripsy under ureteroscopy, and the urethral stones can be completely eradicated by one operation; 5. In case of secondary stones, for example, multiple stones caused by hyperparathyroidism, the simple surgical treatment is ineffective, and it is necessary to carry out the treatment for the function of the parathyroid gland in order to eradicate the stones. Only then can the stones be eradicated, such as the parathyroid glands to be removed, after the body calcium and phosphorus levels return to normal, the stones can gradually disappear and be eradicated.