Many people know that obesity leads to diabetes, that obesity also induces cancer, and that pancreatic cancer is a major contributing factor to diabetes. In fact, the triple association of obesity, diabetes and pancreatic cancer has been confirmed by many credible data. Body mass index (BMI ≥ 35, obese) has a significantly increased risk of pancreatic cancer compared to normal weight people (BMI: 18.5-24.9). In addition, some studies claim that every 5 kg/m increase in BMI increases the risk of pancreatic cancer by 12%. Similarly, diabetes and pancreatic cancer risk have been studied epidemiologically in recent years. One study concluded that 34% of patients with pancreatic cancer have induced diabetes. Thus, the onset of the disease is an important factor in the risk of diabetes and pancreatic cancer when it is associated with the course of diabetes: deceased pancreatic cancer patients usually have an associated history of diabetes. Interestingly, however, it seems that the longer the duration of diabetes, the less likely it seems to develop. In many developed countries, the increased incidence of obesity and diabetes is also positively correlated with the incidence of pancreatic cancer. So, it is natural to wonder if we could screen for pancreatic cancer through the biological markers involved. However, we are currently unsure of the biological mechanism between them. Why does obesity lead to cancer? Obesity is not a direct cancer-causing factor, and the exact mechanism by which it induces the development of cancer is currently unknown. But looking at the lifestyle habits of fat people, it is not difficult to understand the correlation. Obese people tend to prefer foods that are high in calories, animal fats, trans fatty acids and refined carbohydrates, while their intake of dietary fiber, whole grain carbohydrates, vegetables and fruits is insufficient. Such a diet can cause hormonal imbalances in the body. This is because the adipose tissue in obese patients will secrete too much aromatase, which accelerates the conversion of estrogen precursors to estradiol and increases serum estradiol levels. High and low estrogen levels are associated with the occurrence of many types of cancers, such as breast cancer and endometrial cancer. What’s more, overweight and obesity will directly lead to insulin resistance, which causes hyperinsulinemia, affects the regulatory cycle of cell growth, and accelerates gene mutation and cancer development. Obesity or overweight is certainly not good for health, but it is not the slimmer the better, the most appropriate BMI is 22, below 18 is also detrimental to health, will also increase the risk of cancer, such as lung cancer. In terms of cancer prevention, weight control is a good measure. Studies have shown that the relative risk of breast and colorectal cancers can be reduced by 50% in people who actively reduce their weight. Can I lose weight with surgery? Fully known as Laparoscopic Gastric Reduction Surgery, also known as Sleeve Gastrectomy, Gastric Reduction Surgery works by using a laparoscope to cut out the greater curvature of the stomach vertically, resulting in the formation of a small stomach pouch of about 150 cc, which can hold about 4-5 ounces of food. It has the advantage of not requiring the placement of foreign objects in the body and the surgery is highly effective in weight loss. Weight loss surgery can lose 60-80% of your excess weight, and the results can be even better if your post-surgery dietary lifestyle and exercise habits are well coordinated with the support and assistance of a professional health manager.