The generic name for Fen-Phen is ibuprofen, and it is possible for ibuprofen to be teratogenic when taken in pregnancy. Ibuprofen is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic, and analgesic effects of the drug, and there are no extensive case reports or rigorously controlled studies of the drug in human fetuses. Ibuprofen crosses the human placenta and can be found in fetal feces, and studies have reported that the drug functions to constrict the ductus arteriosus of the fetus. There is epidemiologic evidence of an association between ibuprofen and ventral clefts, with similar adverse effects in rats, associated with an increased prevalence of abdominal wall defects and ventricular septal defects. Ibuprofen may be used to relieve mild to moderate pain, such as headache, arthralgia, and migraine, as well as the common cold and high fever associated with influenza. However, it is contraindicated in people who are allergic to the drug, those who have undergone coronary artery bypass grafting, pregnant women, and breastfeeding women, and patients may experience adverse reactions such as pain at the injection site, rash, and dizziness after use. Pregnant women who want to use the drug during pregnancy should use it under the guidance of a doctor to avoid causing abnormal development of the fetus.