Physical incoordination can be caused by a variety of reasons, somatic activities need to rely on muscle, bone, nerve coordination to complete, mainly the central nervous system innervation, any one of the links of abnormalities, may lead to physical incoordination: 1, congenital malformations: seen in infancy, such as congenital stupidity, belong to chromosomal aberrations, in addition to the obvious intelligence backward, accompanied by slow physical development, hypotonia, resulting in The congenital dysmorphism is a chromosomal malformation. In addition, various congenital abnormalities in limb development can directly lead to physical uncoordination; 2. intracranial lesions: trauma, poisoning, inflammation and other damage to the cerebellum, thalamus and brain can cause different types of ataxia, which will lead to poor coordination and balance disorders during movement; 3. extrapyramidal diseases: such as Parkinson’s syndrome, which can appear as resting tremor, muscle rigidity, reduced or slow movement, postural The manifestation of loss of reflexes, of which Parkinson’s disease is common in the elderly, can significantly affect limb coordination. Chorea may present with transient, rhythmic involuntary movements of the trunk and extremities, and also includes the slower choreographic tardive dyskinesia. It also includes dystonia, which manifests as continuous, irregular twist-like involuntary muscle movements; 4. Degenerative lesions of the central nervous system: such as Alzheimer’s disease, which occurs in the elderly and pre-geriatric, causing progressive cognitive dysfunction and behavioral impairment, clinically manifested as memory impairment, aphasia, dysfunction, loss of recognition, personality and behavioral changes. With the development of the disease, motor function becomes worse and worse, and physical uncoordinated performance appears; 5, degenerative spine pathology: common in the cervical spine, lumbar spine disc protrusion, can compress the nerve roots, spinal cord, causing motor dysfunction as well as sensory impairment, appearing limb uncoordination; 6, muscle atrophy: caused by the muscle itself diseases, such as wasting muscle atrophy, muscular dystrophy, polymyositis, etc., and neurogenic muscle atrophy, such as spinal muscular atrophy, poliomyelitis, etc. Muscle atrophy is followed by a decrease in strength, and fine muscle atrophy first appears as an impairment of fine motor movement, resulting in physical uncoordination; 7. Other: when ingesting alcohol, certain drugs, or sleep deprivation, the nervous system is in a state of inhibition, when the activities of the body can be uncoordinated. In addition, poorly healed fracture ends can also cause physical activity uncoordinated situation.