Penicillin is an antibiotic drug and penicillin allergy can be managed by giving antihistamines, glucocorticoids, and epinephrine. Temperatures above 38.5°C may be given NSAIDs to help reduce fever. Allergy to penicillins may cause an allergic reaction, and patients may have erythema, papules, and windsprings on the skin. It is recommended that antihistamines, such as loratadine, ibastine, and levocetirizine hydrochloride be given in combination with a doctor’s advice to alleviate the allergic reaction. If the allergic symptoms are severe and laryngeal edema or shock occurs, it is necessary to go to the hospital in time for treatment. The doctor will evaluate the patient’s condition and use epinephrine hydrochloride injection, triamcinolone acetonide injection, betamethasone acetate injection, etc., if necessary, and give oxygen and symptomatic supportive treatment. If the body temperature exceeds 38.5 ℃ also give ibuprofen, acetaminophen and other drugs, which is conducive to the decline of body temperature. People who are allergic to penicillins should avoid using such drugs in the future. If the symptoms are obvious, go to the hospital in time and ask the doctor to deal with it. Drugs need to be used under the guidance of a medical professional, and should not be used arbitrarily on your own.