The simultaneous prolongation of APTT and PT indicates that the endogenous coagulation pathway and exogenous coagulation pathway are simultaneously impaired, and the common clinical causes are: i. Vitamin K deficiency, where the patient can have a simultaneous prolongation of APTT and PT, treated with intravenous vitamin K supplementation, and the patient can also be treated with plasma infusion. Second, diffuse intravascular coagulation, often caused by infection, trauma and other factors, due to external factors to activate the body’s coagulation pathway resulting in coagulation factor depletion, APTT and PT prolongation at the same time, the need for active treatment of the original disease, plasma transfusion, but also the application of low-molecular heparin anticoagulation therapy.