A swollen mouth and sudden onset, may be acute limited edema, clinical also consider insect bite dermatitis or angioedema. Insect bite dermatitis, the localization of insect bites has flushing, edema, the patient has itching, burning sensation, and even painful sensation. Limited edema, should also be considered angioedema, which is a clinical manifestation of urticaria, is a transient limited edema caused by allergy to a cause. Both are allergic in origin, hence oral antihistamines such as loratadine, cetirizine, ibastine, fexofenadine etc. Topical cold water or 3% boric acid water cold wet compresses, topical glucocorticosteroid cream, such as hydrocortisone butyrate cream, mometasone furoate cream, etc., if accompanied by pain is obvious, can be combined with antibacterial treatment.