Most terminal cancer patients have severe pain, poor appetite, difficulty in breathing, fluid accumulation in body cavity and coma before they die. In addition to these 5 signs, patients will also appear cachexia. Due to the consumption of tumor, the patient will show emaciation, weakness, anemia, edema and even general multi-organ failure. The 5 common signals before the end of life of patients with advanced cancer include: 1. Severe pain: Tumors in advanced cancer may cause painful sensation because of the intake of nutrients from the body, larger tumor growth volume and deeper infiltration into tissues. In the early stage, common painkillers such as ibuprofen and aspirin can be given to relieve the pain; with the development of cancer, opioids and morphine can be used to relieve the pain, which can improve the symptoms; in the late stage of cancer, the drugs even have little effect; 2, poor appetite: patients with advanced cancer need to carry out a lot of treatment, including radiotherapy, chemotherapy, targeted therapy, etc., all have adverse reactions, especially radiotherapy, patients can experience nausea, vomiting and other Patients may experience nausea, vomiting and other digestive reactions, or even vomiting after eating. Some patients with digestive system cancer cannot eat due to cancer blocking the esophagus, and can only supplement nutrition through nasal feeding and intravenous feeding; 3.Respiratory difficulties: patients with advanced cancer can have respiratory difficulties due to various reasons, such as cancer in the respiratory system can compress the airway and directly cause tracheal blockage; cancer in the abdominal cavity can elevate the diaphragm and compress the lungs, resulting in respiratory difficulties; patients are bedridden for a long time and sputum accumulates in the lungs, along with sputum Blocking airway, etc.; 4. Fluid in body cavity: late stage tumor metastases and spreads to thoracic cavity, abdominal cavity or pelvic cavity, which hinders the discharge of body fluid and can form a large amount of fluid. At the same time, the growth of cancer consumes a lot of albumin in the body, resulting in the decrease of plasma osmotic pressure and the inflow of water in the plasma into the body cavity, and the accumulation of fluid can be stored in the body cavity; 5. Coma: In the advanced stage of cancer, the cancer can spread to the whole body and invade the nervous system, resulting in neurological symptoms such as drowsiness and delirium, and in severe cases, coma or even shock.