Dystrophic metaplasia of brain cells is usually referred to as primary hypertension with mental disorders, which is the most common type of mental disorder associated with vascular disease, and refers to the mental disorders that accompany the development of primary hypertension. Psychiatric disorders associated with primary hypertension mainly manifest as neurotic-like syndrome, but also depressive syndrome, hallucinations, delusional states, etc. When the blood pressure increases sharply and a hypertensive crisis develops, it often manifests as a disorder of consciousness. What are the manifestations of dystrophic metamorphosis in diagnosed brain cells? 1, early symptoms: early symptoms of mental disorders are mainly the brain debilitating syndrome. Performance of head discomfort, emotional instability, sleep disorders, inattention, poor memory, reduced work ability, autonomic dysfunction, etc. 2.Limited neurological symptoms and signs: The more common limited neurological symptoms and signs include pseudomyelination palsy, dysarthria, dysphagia, central facial palsy, hemiparesis of different degrees, aphasia, loss of use or recognition, seizures, urinary incontinence, etc. The limited symptoms of cerebral hemorrhage or cerebral infarction vary from site to site, such as ipsilateral hemianopia, spatial disorientation and lack of self-knowledge when the blood supply area of the posterior cerebral artery becomes impaired. 3.Intelligence impairment (dementia): Early stage is limited, i.e. cognitive function is not evenly impaired, and self-knowledge and judgment are well maintained despite memory impairment and intelligence impairment. Anxiety depression only shows excessive attention to one’s own disease, and later on, fear, apprehension, depression and suspicion of disease. The onset of the disease is often sudden, with a phased deterioration. In the later course, some patients develop perceptual disorders and thought disorders, producing various hallucinations and delusional states, such as relationship, victimization, suspicion, jealousy, and delusion of being stolen. It is often a manifestation of mid-stage hypertensive disease. However, there is no impairment of consciousness. Some patients gradually develop from emotional vulnerability to emotional retardation, compulsive crying and laughing, and a few experience emotional outbursts. As the disease progresses, if somatic comorbidities, trauma, acute environmental changes occur, especially in the case of acute cerebrovascular accidents, the dementia symptoms will increase in a stepwise manner and become full-blown dementia in the late stage. In the presence of hypertensive crisis or encephalopathy, the patient may develop impaired consciousness, which may be accompanied by terrifying hallucinations or fragmentary delusions, excitement, impulsivity, incoherent speech or pseudotumor-like syndrome (signs of elevated cranial pressure). In some patients, after recovery of consciousness, there are still manic or depressive-like manifestations for a short period of time. 4, cerebrovascular disease with mental disorders: cerebrovascular disease with mental disorders can have memory, intellectual impairment and limited neurological symptoms signs. Most patients have a graded and fluctuating course of the disease, with some deteriorating due to stroke, and only a few patients are in remission. The duration of the disease is about 2 months in short cases and more than 20 years in long cases, with an average of about 5 years. Half of the patients have hypertension, some have coronary artery disease, diabetes mellitus, and hyperlipidemia. Patients’ symptoms of hypertension, carotid murmur, emotional instability with transient depressed state of mind, crying or explosive laughter, transient clouding of consciousness or delirium episodes are often exacerbated by further infarction. Personality remains relatively intact, but significant personality changes such as apathy, lack of self-control, or more prominent pre-existing personality traits such as egocentricity, paranoia, or irritability may also occur. Most patients die due to recurrent acute cerebrovascular attacks or coronary heart attacks or secondary infections. 5. Somatic symptoms: often headache, vomiting, vertigo, elevated blood pressure, transient spasm or sclerosis of the arteries in the fundus, changes in the heart seen on X-ray, changes in renal function seen on laboratory tests, etc.