The normal value of BNP is 0-100 pg/mL. clinical significance of BNP: BNP <100 can basically exclude left heart failure, but for patients with cardiac insufficiency, even if BNP <100, with lower limb edema, chest and abdominal effusion, chest tightness and shortness of breath symptoms, combined with cardiac ultrasound, the diagnosis of heart failure can also be considered. BNP >100, if combined with nocturnal paroxysmal dyspnea, BNP is also seen in severe infections, such as sepsis and septicemia. BNP can also be seen in severe kidney disease with renal insufficiency. after inflammation is controlled, renal function improves and BNP can be rapidly reduced to normal. BNP can also assess the effect of heart failure treatment. if BNP drops to less than 50% of the original level after active treatment, consider the treatment effective.