The baby wakes up in the middle of the night and refuses to sleep may be related to the environmental temperature discomfort, hunger, indigestion, calcium deficiency, according to the baby’s situation to adjust the environmental temperature, relieve hunger, improve indigestion or supplement cod liver oil. 1. Environmental temperature discomfort: room temperature is too low or too high in the middle of the night, making the baby uncomfortable, waking up in the middle of the night and refusing to go to sleep, at this time, pay attention to adjusting the room temperature, to create a suitable sleeping environment for the baby. 2. Hunger: babies may wake up in the middle of the night because they are hungry and do not want to go to sleep, they should be given reasonable feeding to relieve the baby’s hunger. 3. Indigestion: may be due to the baby’s digestive system is not mature enough, bloating, abdominal pain and other gastrointestinal discomforts, affecting the baby’s sleep, you can give the baby some drugs to help digestion, such as probiotics (Bacillus subtilis bifidus granules), etc., to promote gastrointestinal peristalsis, but should be used under the guidance of a physician. 4. Calcium deficiency: baby calcium deficiency will also be unable to sleep, it is recommended that under the guidance of a physician in a timely manner to supplement calcium, usually can also be more sunshine, to promote the absorption of calcium. If the baby often occurs this situation, it is recommended to go to the relevant professional department for examination and treatment.