Diabetic patients with prolonged substandard blood glucose control can cause diabetic plant nerve dysfunction. Patients show symptoms such as abnormal sweating, difficulty in urination as well as gastroparesis and abdominal distension. Clinical treatment mainly gives nerve-nourishing drugs, such as vitamin B12 to repair nerves, lipoic acid to resist oxidative stress, and epalrestat to reduce the amount of sorbitol, thus reducing the damage to nerves, as well as improving the treatment of nerve-nourishing microcirculation drugs. Of course, active treatment of the original disease, strengthen the control of blood sugar is the most basic and key, adjust the glucose lowering program so that blood sugar control to meet the standard, fasting blood sugar control below 7.0mmol/L, 2 hours after meals blood sugar control below 10mmol/L. If the patient’s sweating abnormality is more obvious, he can be given symptomatic treatment such as glutathione and ginseng granules.