Pain in the TMJ area caused by TMJ disorders can be treated with localized injections of medications such as prednisone and lidocaine for closure. The medication should be prescribed by a doctor. TMJ disorder is an oral disease of unknown etiology and may be caused by poor chewing habits. It can be corrected by orthodontics and by changing bad chewing habits. However, if TMJ disorder causes severe pain, localized sealant therapy can be used to relieve pain symptoms. Sequestration involves mixing prednisolone with lidocaine and injecting it into the painful area, which can achieve a good anti-inflammatory and analgesic effect. Prednisolone may cause secondary infections and lidocaine may cause localized skin rashes, and all of the above medications should be injected by a medical professional. When suffering from TMJ disorder, it is recommended to go to the hospital in time, to clarify the cause of TMJ disorder, and under the guidance of the doctor for treatment.