HFMD is a common and generally mild but highly contagious infectious disease that can be caused by a variety of enteroviruses and is easily contracted by people under 4 years of age. It occurs in summer and fall, with a peak in September. However, the disease can occasionally cause complications such as myocarditis, pulmonary edema, and aseptic meningoencephalitis, and can lead to death in severely ill children due to rapid progression of the disease. Therefore, HFMD needs to be treated according to the child’s condition, and need not be taken too seriously, nor too lightly, too lightly may result in serious consequences. Because of the mild symptoms, patients who may have only a hand and foot rash at the beginning often visit the dermatology department for the first time. The main lesions are red papules, papules and blisters about the size of rice grains to green beans on the palmoplantar and dorsal margins of the fingers and toes, with a red halo around the blisters, while similar lesions can be found on the oral cavity, pharynx, soft palate, cheek mucosa, tongue and gums, and lesions can also be seen near the buttocks and anus, and occasionally on the trunk and extremities, or even in general.