You can take ibuprofen for toothache to relieve pain. In addition to taking ibuprofen for pain in the acute stage of tooth inflammation, you can also take antibiotics to reduce inflammation, such as cephalosporin, amoxicillin, erythromycin, metronidazole tablets and ornidazole tablets. If the toothache leads to swelling of the face, lymph node enlargement, accompanied by high fever and other systemic symptoms, you can use intravenous infusion to reduce inflammation, mainly using penicillin antibiotics with ornidazole combined anti-inflammatory. The most common case of severe pain in the teeth is endodontitis, in addition to taking painkillers and anti-inflammatory drugs in the treatment, you also need to go to the hospital to do root canal treatment. Root canal treatment removes the infected nerve and eliminates the inflammation before the pain is completely resolved. Wisdom tooth pericoronitis and acute periapical inflammation can also cause severe pain, in the acute stage also need to take anti-inflammatory drugs to reduce inflammation, and when the acute stage is over, the wisdom teeth should be extracted.