Depression with anxiety painful features generally cannot be cured by itself, although the cause of the disease is not fully defined at present, it has certain biological and sociological features. For patients with abnormal neurological conditions, the disease can be aggravated without treatment, even leading to increased cognitive impairment and social decompensation, while for patients affected by psychosocial factors, adverse events that are not lifted and the root cause of depression and anxiety about life is not clearly defined can persist or aggravate depression with anxiety painful features, so one cannot hope for self-healing.