Blood cancer is the common name of leukemia. There is no such thing as 15 signs before death of blood cancer. Since each person’s condition and disease progress are different, it is not possible to determine which symptom represents imminent death, but it can be judged appropriately by the symptoms of late stage leukemia. The common ones are heavy bleeding, high fever that does not subside, enlarged liver and spleen, enlarged lymph nodes, edema, respiratory distress, and impaired consciousness. 1. Heavy bleeding: there will be more than bleeding from the nose and mouth to form hematomas, as well as skin petechiae and bruising, accompanied by massive coughing up of blood and hematuria, blood in the stool, etc., and no significant effect by pressure to stop bleeding or application of hemostatic drugs. 2. High fever that does not subside: patients with leukemia in the late stage will have repeated of fever, which can reach about 40℃. After the application of hormonal drugs, the temperature may temporarily decrease, but it will rise within a short period of time. 3. Enlarged liver and spleen, enlarged lymph nodes: The abdomen is enlarged and lumpy, and the lymph nodes in the neck and axilla are enlarged. 4. 5. Difficulty in breathing: due to anemia and leukemia cell infiltration will affect the respiratory function, symptoms such as difficulty in breathing and shortness of breath will appear, and oxygen is needed to relieve the symptoms; 6. Impaired consciousness: at the end of the disease, there will be gradual loss of consciousness, unclear consciousness, unable to wake up and answer; 7. Patients in the terminal stage of the disease, family members should closely observe the condition and try to accompany them at the bedside. They can supplement nutrition appropriately, make patients maintain an optimistic state of mind as much as possible on the basis of prolonging life, communicate more with patients, and give humanistic care as much as possible.