Symptoms of the acute phase of chronic leukemia: First, the appearance of unexplained fever, anemia bleeding aggravated by skeletal muscle pain. Second, progressive enlargement of the spleen, the causes of which are classified into two categories, one is infectious splenomegaly and the other is non-infectious splenomegaly. Third, progressive decrease or increase of platelets not caused by drugs. The main function of platelets is coagulation and hemostasis. It is involved in the protection of the cell endothelium. Fourth, primitive cells type I and II, in the blood as well as in the bone marrow is greater than 10%. Fifth, peripheral blood basophils greater than 20%, in the Richter stained blood smear is light brownish red and covered by kidney-shaped or lobulated particles, the outline is often unclear, the particles are alkaline and easily stained, purple in color and 0.1-0.2 microns in diameter. There are more developed Golgi apparatus and few mitochondria within the spores on electron microscopy.