The most common causes of pain in the depression between the two chests are gastrointestinal diseases, heart diseases, but also chest wall diseases, lung and pleural diseases. 1. Gastrointestinal diseases: esophagitis, gastroesophageal reflux, gastritis, gastric ulcer and other diseases caused by gastric acid reflux stimulation of the esophageal mucosa, pancreatitis and other diseases predisposition to pain can be caused by the posterior sternum under the jaboturm of the two chest between the depression of pain. 2. Heart disease: coronary heart disease, angina pectoris, myocardial infarction, viral myocarditis, pericarditis and other diseases cause myocardial ischemia and hypoxia, myocardial injury and necrosis, inflammation stimulation, etc. can appear in the anterior region of the sternum after the pain. 3. Diseases of chest wall: sternal and soft tissue injury caused by trauma, costochondritis, intercostal neuritis, and hyperplasia of the raphe can also cause pain in the depression between the two chests at the heart. 4. Lung and pleural diseases: lung infection, lung cancer invading the tissue behind the sternum, pleurisy, pleural mesothelioma and other diseases can also cause pain in the depression between two chests behind the sternum. Pain in the depression between the two chests, it is recommended to go to the hospital for further diagnosis and treatment.