Glibenclamide is suitable for patients with type 2 diabetes mellitus whose efficacy of dietary control alone is unsatisfactory, where the patient’s pancreatic islet cells have some insulin secretion and there are no serious complications. Glibenclamide is contraindicated in type 1 diabetes mellitus, type 2 diabetes mellitus with ketoacidosis, coma, severe burns, infections, trauma and major surgery and other stressful conditions, hepatic and renal insufficiency, allergy to sulfonamides, leukopenia patients. Weakness, high fever, nausea and vomiting, hyperthyroidism, and the elderly should use the drug with caution. Regular monitoring of blood glucose, urine glucose, urine ketone bodies, urine protein and liver and renal functions, and eye examinations, etc., should be performed during the use of the drug. Glibenclamide should always be used under medical supervision.