The principle of treatment for extra-heavy craniocerebral injury is emergency resuscitation and correction of shock, which triggers extra-heavy craniocerebral injury is an injury to craniocerebral tissues caused by violence acting directly or indirectly on the head, and the degree of injury can be determined according to the Glasgow Coma Score. Extra-heavy craniocerebral injury is treated with emergency resuscitation, correction of shock, debridement, anti-infection and surgery as the main treatment principle. In emergency care, it is necessary to pay attention to symptom observation and care, keeping the airway open, correcting shock, general care requires lying down, preventing intracranial infections, hyperthermia care, strengthening basic care, hibernation care, nutritional support and so on. For patients with extra-heavy craniocerebral injury entering coma, nursing care is an extremely long process, so we should pay attention to the changes of the condition in time and cooperate in many aspects to promote the early recovery of patients. The risk of extra-heavy craniocerebral injury is that the patient can not be awakened, and it is necessary for the patient’s family to be psychologically prepared to cooperate with the doctor’s treatment plan and take care of the patient. For the late stage of recovery of extra-heavy craniocerebral injury, it is necessary to intervene in the rehabilitation therapy as early as possible, using decongestive drugs such as mannitol according to the doctor’s instruction, and cooperating with nutritive nerve drugs such as cytarabine sodium and ganglioside to promote its recovery. Patients and their families should cooperate with doctors to help the disease recovery.