Rheumatoid arthritis is a wandering joint swelling and pain caused by rheumatic fever, often involving large joints such as the knee. Treatment requires anti-infective therapy such as penicillin for rheumatic fever, non-steroidal anti-inflammatory drugs such as aspirin, and anti-inflammatory therapy such as glucocorticoids such as prednisone acetate. 1. Rheumatic fever is a systemic connective tissue inflammation caused by streptococcal infection, mainly involving the joints, heart, nerves, skin and subcutaneous tissues, wandering joint swelling and pain is a common clinical manifestation, also known as rheumatoid arthritis. The affected joints are mainly large joints, and the knee (knee joint) can be involved. Usually, it can be improved within 1 month. 2. The treatment of rheumatic fever requires antibiotics mainly penicillin, such as penicillin allergy can choose cephalosporin, azithromycin, erythromycin, etc., and at the same time need to be used in conjunction with aspirin, indomethacin, etc., the condition of the serious need for glucocorticosteroids, such as prednisone acetate, dexamethasone, etc. treatment. Knee joint pain can also be caused by other reasons, not unauthorized use of drugs, it is recommended to consult the rheumatology and immunology department to clarify the cause of the disease, and comply with the doctor’s instructions to standardize the treatment.