Symptoms of Undifferentiated Connective Tissue Disease include malaise, low-grade fever, rash, joint pain, edema and Raynaud’s phenomenon. The specific cause of undifferentiated connective tissue disease is still unclear, the disease has some of the clinical manifestations of connective tissue disease but does not meet the diagnostic criteria for a particular disease, clinical symptoms include fatigue, low-grade fever, skin rashes, joint pain, edema, lymphatic enlargement, etc., of which the skin damage, joint muscle lesions and vasculitis Raynaud’s phenomenon is more common. Undifferentiated connective tissue disease may also present with hematologic lesions, pulmonary and cardiac lesions, kidney damage, neurological damage, etc. Symptoms are complex and atypical, and diagnosis requires gradual exclusion of other diseases, while laboratory screening for autoimmune antibodies may provide clues for the diagnosis of the disease. It is recommended that patients diagnosed with Undifferentiated Connective Tissue Disease go to the Department of Rheumatology and Immunology of regular hospitals in a timely manner, and under the guidance of the doctor to carry out standardized treatment, so as to avoid delays in the condition.